The University of Florida (Center for Pharmacometrics and Systems Pharmacology) in collaboration with Metrum Research Group and the ISoP Student Leadership Committee, will present a tutorial session to review case studies in PBPK and QSP modeling and simulation using mrgsolve in R. mrgsolve (https://mrgsolve.github.io) is a free, open-source modeling and simulation platform to support ODE-based model development in R.
The workshop is scheduled to take place at the University of Florida-College of Pharmacy (Orlando Lake Nona Campus) Classroom 334 on March 24 (Saturday) from 1:30 pm – 5:30 pm. Course slides, data, and code are provided for all examples. Attendees should have knowledge and experience in population PKPD modeling and a laptop with WiFi internet capability. Attendance is free and open to all.
Please register through this link: https://www.eventbrite.com/e/case-studies-with-mrgsolve-pbpk-and-qsp-model-implementation-and-utilization-in-r-tickets-43348159512 if you plan to attend. Seats are limited.
- mrgsolve overview (brief tutorial)
- PBPK model characterizing drug-drug interactions between HMG-CoA reductase inhibitors and cyclosporine (Yoshikado et al. 2016; PMID 27170342)
a. Sensitivity analyses
b. Parameter estimation
- Evaluation of combination chemotherapy regimens using a QSP model for MAP kinase signaling in colorectal cancer (Kirouac et al. 2017; PMID 28649441)
a. Create complicated input data sets
b. Options for parallelizing simulations
Yi Ting (Kayla) Lien, M.S.
ISoP Student Leadership Chair
University of Florida