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February 3rd New Jersey Chapter Meeting Presentations by Dr France Mentre, Dr. Stephen Duffull, and Dr. Andrew Hooker


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On February 3rd, the New Jersey Local Chapter of ISoP hosted an evening event, highlighted by presentations by Dr France Mentre, Dr. Stephen Duffull, and Dr. Andrew Hooker.

The presenters have graciously made their presentations available.

Dr France Mentre, INSERM and University Paris Diderot, Paris, France

Bayesian Fisher information matrix for predicting estimation error and shrinkage of individual parameters in NLMEM

In this Presentation. Dr. Mentre describes standard errors of bayesian estimates and shrinkage.

Dr Stephen Duffull, School of Pharmacy, University of Otago, Dunedin, New Zealand

Identifiability of Population PKPD Models

In this presentation, Dr Duffull focused on why identifiability is important, building up from a simple linear example to explain the principle, to more complex examples, and finally to show the interdependence of model identifiability and parameterization. Software is also available to do these anlayses:

www.pharmacometrics.co.nz/download

Dr. Andrew Hooker, Department of Pharmaceutical Biosciences Uppsala University Sweden

Leveraging Uncertainty in Pharmacometric Models

Dr Hooker introduced the concepts of model averaging during his presentation. He also highlighted that software called modelAVERAGE on www.bluetree.me is available to perform this type of work.

His presentation also included recent work on model based adaptive optimal designs and software supporting these approaches.

poped.sf.net

MBAOD – R package to perform MBAOD

Many thanks to all three presenters, and for making their presentations available.