DDMoRe: An Introduction and Demo

Title: DDMoRe: an Intorduction and Demo
Presenter(s): Mike K Smith
Date(s): June 29th, 2016
Time: 12:00 pm EDT


Background: The Drug Disease Model Resources (DDMoRe) consortium has been created to improve the quality, efficiency and cost effectiveness of Model-Informed Drug Discovery & Development.

In model-informed drug development, information from a wide array of sources can be integrated into models to describe and predict the behavior of complex disease/biological systems and drug actions. The consortium will deliver a platform as resource for models and knowledge sharing, based on standards to ensure consistency of evidence. Academia, industries and health authorities can rely on this platform in making decisions about development, approval of new medicines and improvement of therapy with existing drugs.

DDMoRe will deliver a model repository (repository.ddmore.eu), interoperability framework and tools, workflow tools and training courses on model informed drug discovery and development (MID3) using the DDMoRe tools.

You can find out more about DDMoRe on ddmore.eu.

In this first webinar, I would aim to introduce you to the DDMoRe repository and show you how you could use a model from the repository (Simeoni tumour growth inhibition model - http://repository.ddmore.eu/model/DDMODEL00000006) to address research questions.

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Interesting opportunity Mike, is there a specific target audience? For how long is the webinar scheduled?

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The webinar will run for approximately one hour, where I will give an introduction to what the DDMoRe project is, what our main deliverables are, where we’ve got to (with only 2 months left to run!), give a demonstration of the model repository - how to find models, what to do with them - and working with the Simeoni model of tumour growth inhibition across a number of different tools, using our interoperability framework.

The IMI DDMoRe project is co-funded between EU taxpayers and pharmaceutical industry, but once the project ends we will have a DDMoRe foundation which is open to all to join, contribute and support.

Hope you’ll be able to join the webinar next week!



Here is the Youtube link for tomorrow’s session -

Great Mike, thanks on behalf of the whole DDMoRe team and good luck tomorrow!

@MikeKSmith is there an API that can be used to access the model repository?

What is the uptake of this tool in the industry? Or is this still largely academic in nature, that too ad hoc after model development in a different software?

How do you anticipate this interface to align in the growing age of open source solutions?

Great work by the DDMoRe group. This is great platform if it can be used on a larger scale !
How would one start using these tools?

Vijay, thanks for your questions.

At present, the repository can be accessed, browsed and models downloaded via the website interface at http://repository.ddmore.eu. Ultimately we would like to be able to access publicly available models in the repository directly via the ddmore R package, so that users can access and use models direct from the repository without having to manually download the .mdl files. Upload to the repository just now is only via the website.

At present the tools are being piloted in a few EFPIA companies, but mainly as a “proof of concept” rather than production tools.

I hope that the DDMoRe standards (MDL / PharmML / Standard Output object) might be a “lingua franca” for models that could then be converted to any number of tools & solutions, open source or not. As you saw, we have converters for Monolix & simulx, NONMEM & PsN, BUGS, PFIM and PopED. I would really hope in future to be able to create similar converters (perhaps starting from the R representation of MDL) for PKPDsim, mrgsolve, RxODE, deSolve and also via PharmML for Stan… The systems biology world has SBML as the model exchange standard which has prompted lots of development of new tools, including many that are open source or freely available. I hope that the DDMoRe standards might do likewise, providing a “hub” to connect tools.

The next public release of the software is due at the end of July. We will provide additional communication around that time with details of how to get it, install it and use it.