Presenter: Wojciech Krzyzanski, PhD, University at Buffalo
Objectives: Models using delay differential equations (DDEs) are getting increasingly popular in the analysis of data exhibiting delays. Many pharmacometric software (Phoenix NMLE, Monolix, MATLAB, Berkeley Madonna) support DDE solvers to facilitate DDE based model development. Recently, a DDE solver has been implemented in NONMEM as ADVAN 16. The objective of this presentation is to introduce basic concepts underlying DDE based models and show how they can be developed using ADVAN16.
- Introduction to DDEs
- Overview of RADAR5 DDE solver
- Basics of ADVAN16
- Examples of DDE models
Rheumatoid arthritis development in collagen-induced arthritic mice
Tumor growth inhibition in xenograft mouse model
Erythropoietin stimulation of RBCs
- Challenges and limitations
Duration : 45 min (presentation)+ 15 min (Q&A)
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